LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher …

Feb 1, 2012 · The LDHA gene provides instructions for making a protein called lactate dehydrogenase-A, which is one piece (subunit) of the lactate dehydrogenase enzyme. Learn about this gene and …

Feb 1, 2023 · In this review, we introduced lactate dehydrogenase A (LDHA), predominantly involved in glycolysis, which provides energy for T cells and plays a dual role in disease by mediating lactate …

Jan 15, 2026 · LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include Fanconi-Bickel Syndrome and Glycogen Storage Disease Of Heart, Lethal Congenital. …

This review summarizes what is currently known about the function of LDHA and identifies areas that would benefit from further exploration. The current knowledge of the role of LDHA in the brain and its …

Jul 1, 2025 · Due to their metabolic characteristics, tumors often exhibit abnormal LDHA expression, which meets their growth requirements by promoting glycolysis and lactate production.

Mar 5, 2024 · Reciprocally, infiltrating macrophages produce LDHA-containing extracellular vesicles to promote glioblastoma cell glycolysis, proliferation, and survival.

Lactate dehydrogenase A (LDHA) is upregulated in multiple cancer types and contributes to the Warburg effect. Several studies have found that many tumor-related genes have subtypes and play …

Sep 14, 2025 · Gene target information for LDHA - lactate dehydrogenase A (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Mutations in the LDHA gene result in the production of an abnormal lactate dehydrogenase-A subunit that cannot attach (bind) to other subunits to form the lactate dehydrogenase enzyme. A lack of …