Phase I dose-finding studies aim at identifying the maximum tolerated dose (MTD). Often, several dose-finding studies are conducted with some variation in the administration mode or dose panel. For ...

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by impairments in social ...

Background While female sex has historically been associated with worse outcomes following surgical aortic valve replacement, ...

Introduction Mental disorders affect nearly one billion people worldwide, posing major challenges to public health. While conventional treatments like psychotherapy and pharmacotherapy are effective ...

Objective To evaluate systematic reviews of randomised controlled trials (RCTs) on the effects of exercise on general cognition, memory and executive function across all populations and ages. Methods ...