Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles ...

Furthermore, the number of osteocyte dendrites-elongated structures that help in regulation of bone remodeling-was reduced in the mutant mice. Additional genomic analysis of cells obtained from the ...

Osteogenesis imperfecta (OI) refers to a group of rare genetic bone disorders that results in the formation of fragile bones. In patients with OI, the matrix that makes up the bone has been found to ...