Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant ...

The c-Kit (CD117), receptor tyrosine kinase (RTK), and its ligand stem cell factor (SCF) are necessary for the development of embryos and the progression of human cancer. In gastrointestinal stromal ...

Toronto, ON - Canadian researchers have identified a stem-cell-factor receptor, known as the steel factor receptor, or c-kit, that appears to play an important role in mediating the mobilization of ...

This is a preview. Log in through your library . Abstract Establishment of the mammalian germ line is a prerequisite for fertility of the adult animal but we know surprisingly little about the ...

Bortezomib-Based Versus Nonbortezomib-Based Induction Treatment Before Autologous Stem-Cell Transplantation in Patients With Previously Untreated Multiple Myeloma: A Meta-Analysis of Phase III ...