Findings suggest that new genes can form by repurposing fragments of ancestral genes while incorporating entirely new coding regions (the protein-coding parts of the DNA). This innovative concept ...
EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants ...
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Replacing large mouse gene regions with human DNA
Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...
Understanding human gene function in living organisms has long been hampered by fundamental differences between species.
A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the ...
Around 98.5% of human DNA is non-coding, meaning it doesn’t get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for ...
The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible ...
What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...
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