Comparative effectiveness research has been the target of recurrent criticism in some political circles, with opponents claiming it’s the “gateway to rationing” or it encourages “cookbook medicine.” ...

Issue brief from Ellen-Marie Whelan and Sonia Sekhar explains how comparative effectiveness research will help deliver better health care. When consumers shop for most products in America, we have the ...

The American Recovery and Reinvestment Act of 2009 provided $1.1 billion for comparative effectiveness research (CER). The Patient Protection and Affordable Care Act established the Patient-Centered ...

The US House of Representatives is considering legislation (HR 485) that would prohibit the use of the quality-adjusted life-year (QALY) and similar measures for coverage and payment determinations ...

Understanding the clinical nuances of when and to whom services render the greatest benefit requires more research. The type of research that addresses this issue is commonly labeled comparative ...

We analyzed deidentified data from an EHR-derived database for patients with advanced non–small cell lung cancer (aNSCLC) at their first line of treatment. Our novel imputation method involved (1) ...

In the article that accompanies this editorial, Lu et al 5 conducted a systematic review on the use of instrumental variable (IV) methods in oncology comparative effectiveness research. The main ...

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of ...

The messenger RNA (mRNA)–based vaccines BNT162b2 and mRNA-1273 are more than 90% effective against coronavirus disease 2019 (Covid-19). However, their comparative effectiveness for a range of outcomes ...